Lasix works in the kidney to increase blood filtration and diuresis. Lasix binds to the Na + / K + / 2Cl-co-transporter on the membrane of the thick ascending limb of the loop of Henle and blocks it. Because electrolytes cannot be reabsorbed in the thick ascending limb of the loop of Henle, and reabsorption is slowly blocked in the proximal and distal tubules, an increased amount of electrolytes in the primary urine will pass through the nephrons and get eliminated in the urinary system.
Lasix is a strong diuretic and causes the secretion of 15-25% of filtered sodium. Lasix in larger doses may inhibit electrolyte transport by inhibiting the Na + / K + / 2Cl-co-transporter in other tissues. Such a Lasix effect in the middle ear can lead to electrolyte imbalance and cause ototoxicity. Lasix comes in pill and injection form, with injections reserved for patients who are unable to take medication by mouth, or in urgent clinical situations.

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Lasix Use: Lasix is used for treatment of hypertension, edema cases related to congestive heart failure, cirrhosis of the liver and kidney disease, including nephrotic syndrome. Lasix is suitable when it is necessary to use medicine with a strong diuretic. In emergency cases, acute pulmonary edema requires aquick diuretic effect, so in these cases Lasix is given intravenously or intramuscularly.
In cases of hypertension an oral form of Lasix is used. It can be used independently or in combination with other antihypertensives. It should be used only when other antihypertensives and diuretics are not effective. Lasix is used in prevention of acute renal failure and can be used in patients with renal failure. Lasix is used when forced diuresis is required, in case of poisoning with drugs or other poisons, and is also used for flushing the kidneys when there is a risk of acute renal failure.
Considering that the use of Laxis causes the loss of potassium ions, it is nearly always used in combination with potassium supplements, especially in cases when it is used to alleviate hypertension, because the loss of potassium ions is potentially harmful for heart activity.

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Lasix Side Effects: Lasix should not be used by patients with anuria. Diabetics should also be careful because Lasix increases the concentration of glucose in the blood. Patients allergic to sulfonamides may be allergic to Lasix. Because Lasix us, some patient`s skin can become sensitive to sunlight.
In patients with liver cirrhosis and ascites treatment with Lasix is best performed in the hospital. In a coma or a state of lowelectrolyte concentration, therapy should be performed until the body`s state improves, because the use of Lasix results in potassium loss and metabolic acidosis. There have been reported cases of tinnitus and reversible or irreversible hearing loss. Many cases confirm that Lasix's ototoxic effects correlated with starting Lasix too abruptly.

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Other Possible Side Effects of Lasix: These include pancreatitis, icterus, systemic vasculitis, interstitial nephritis, tinnitus and hearing loss, paresthesia, dizziness, blurred vision, aplastic anemia, thrombocytopenia, exfoliative dermatitis, hyperglycemia and hyperuricemia.

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